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The researchers have begun studies testing whether epigenetic changes play a role in this new type of treatment-resistant prostate cancer. When they looked at tumor samples collected before abiraterone and enzalutamide were in use, neuroendocrine prostate tumors were twice as prevalent as FGF-driven tumors.

In samples taken from to —after the drugs were approved by the Food and Drug Administration—FGF-driven tumors were approximately twice as common as neuroendocrine tumors. The findings may have implications for trials of FGF inhibitors, Dr. Nelson said. For example, one FGF receptor inhibitor, dovitinib , has already been tested in patients with metastatic prostate cancer.

The response rate for patients receiving the drug was modest. But, explained Dr. The ultimate approach for treating metastatic prostate cancer, he continued, may be to target more than one signaling pathway up front. These trials showed that men with hormone-sensitive metastatic prostate cancer treated with standard androgen-deprivation therapy ADT plus docetaxel or abiraterone live longer than men treated with standard ADT alone.

New Subtype of Treatment-Resistant Prostate Cancer - National Cancer Institute

If studies show that FGF signaling pathway inhibitors extend survival in men with androgen-independent metastatic prostate cancer that is dependent on FGF signaling, the long-term strategy might be to incorporate FGF inhibitors as part of first-line therapy for metastatic disease instead of waiting for androgen resistance to develop, Dr.

Nelson speculated. We welcome your comments on this post. All comments must follow our comment policy. September 9, , by NCI Staff.

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September 3, , by NCI Staff. July 25, , by NCI Staff.


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Prostate Cancer Signaling Networks Genetics And New Treatment Strategies

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Integrating Imaging & Genomics in the Management of Prostate Cancer - Robert Reiter, MD

Managing Cancer Care. Finding Health Care Services. Neta Erez , Morgan L. Humanized mouse models to study human diseases. Cancer-associated fibroblasts and tumor growth--bystanders turning into key players. Arne Ostman , Martin Augsten.

Genetics and biology of prostate cancer

DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. Migratory neighbors and distant invaders: tumor-associated niche cells. Jared Wels , Rosandra N. Kaplan , Shahin Rafii , David Lyden. Infiltration of COXexpressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth.

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Related Papers. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, "Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies" provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

Epigenetic Gene Silencing in Prostate Cancer3. Inherited Genetic Changes in Prostate Cancer4. Androgen Receptor in Prostate Cancer Progression7.